Key result
High triglyceride-glucose index links to ~306% greater odds of high residual SYNTAX scores post-STEMI PCI.
Why the study?
The relationship between triglyceride-glucose index and residual SYNTAX score in STEMI patients undergoing primary PCI was not well established.
Is a high triglyceride-glucose index associated with a higher residual SYNTAX score in patients with STEMI undergoing primary PCI?
Observational (n=663)
No
Is a high triglyceride-glucose index associated with a higher residual SYNTAX score in patients with STEMI undergoing primary PCI?
A high triglyceride-glucose index is an independent predictor of a high residual SYNTAX score in STEMI patients undergoing primary PCI, suggesting a link between insulin resistance and incomplete revascularization.
May aid residual risk stratification after STEMI PCI; hypothesis-generating pending prospective validation.
Purpose: The triglyceride-glucose index (TyG) is an important parameter that reflects insulin resistance and its use has increased recently. Its relationship with cardiovascular diseases has been shown in previous studies. Our aim was to investigate the association of residual SYNTAX score (rSS) with TyG index in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention. Materials and Methods: A total of 663 STEMI patients who underwent primary percutaneous coronary intervention were included in the study. The patients were divided into 2 groups according to the TyG index level as high and low. The cut-off value for the TyG index was determined as 9.61 by ROC analysis. Coronary artery disease severity was calculated for both groups besides baseline clinical and demographic variables. Results: A total of 281 patients were evaluated in the high TyG index group and 386 patients in the low TyG index group. A rSS above 8 was considered high. The proportion of patients with high rSS in the increased TyG index group was found to be significantly higher than in the other group [114 (40.6) vs. 54 (14.0)]. In addition, higher TyG index is determined to be the independent predictor of higher rSS in logistic regression analysis. Conclusion: High TyG index had a strong association with rSS and higher TyG index was an independent predictor of increased rSS in patients with STEMI
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Avcı et al. (2023) conducted an observational in ST-segment elevation myocardial infarction (STEMI) (n=663). High Triglyceride-glucose (TyG) index (>9.61) vs. Low TyG index (≤9.61) was evaluated on High residual SYNTAX score (>8) (OR 4.057, 95% CI 2.737-6.013, p=<0.001). A high triglyceride-glucose index was an independent predictor of a high residual SYNTAX score in patients with STEMI undergoing primary percutaneous coronary intervention (OR 4.057, p<0.001).
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