Key result
A higher triglyceride-glucose index independently predicted major adverse cardiac events (HR 1.8004), and its combination with the residual SYNTAX score further improved risk prediction in patients with type 2 diabetes undergoing PCI.
Why the study?
Whether combining the residual SYNTAX score and triglyceride-glucose index improves the predictive ability for MACEs in patients with T2DM undergoing PCI was unknown.
Does a combination of the residual SYNTAX score and the TyG index improve the prediction of intermediate-term major adverse cardiac events in patients with type 2 diabetes mellitus undergoing PCI?
Population
633 consecutive patients with T2DM undergoing PCI
Comparison
Stratification by TyG index and rSS cutoff values
Design
Observational cohort study
Follow-up
Median 18.83 months
Authors
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May refine post-PCI MACE risk stratification in T2D; leaves open need for prospective validation before clinical use.
Cohort (n=633)
No
Does a combination of the residual SYNTAX score and the TyG index improve the prediction of intermediate-term major adverse cardiac events in patients with type 2 diabetes mellitus undergoing PCI?
Hazard Ratio: 1.8004 (95% CI 1.2603–2.5718)
Absolute Event Rate: 21.4% vs 9.8%
p-value: p=0.0012
Xiong et al. (2022) conducted a cohort in Type 2 diabetes mellitus undergoing percutaneous coronary intervention (n=633). High triglyceride-glucose (TyG) index vs. Low triglyceride-glucose (TyG) index was evaluated on Composite of major adverse cardiac events (MACEs), including all-cause death, nonfatal myocardial infarction, and unplanned repeat revascularization (HR 1.8004, 95% CI 1.2603-2.5718, p=0.0012). A higher triglyceride-glucose index independently predicted major adverse cardiac events (HR 1.8004), and its combination with the residual SYNTAX score further improved risk prediction in patients with type 2 diabetes undergoing PCI.