Key result
Biomarker screening identifies moderate to high CVD risk via hsTnI in ~10% of healthy adults.
Why the study?
Many Malaysians are unaware of their cardiovascular disease risk, and measuring biomarkers in the general population may help identify at-risk individuals before symptomatic CVD onset.
Population
2744 self-declared healthy volunteers from the general population in Johor, Malaysia
Comparison
Levels of hsTnI, BNP, and homocysteine biomarkers assessed for CVD risk
Design
Observational cohort study
Authors
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Should not yet change screening practices; leaves open utility of biomarker-guided risk assessment in asymptomatic Asian populations.
Observational (n=2,744)
A significant proportion of self-declared healthy individuals in Malaysia have elevated cardiovascular biomarkers, suggesting potential utility for population-level biomarker-guided risk screening.
Sickan et al. (2020) conducted an observational in General population (self-declared healthy) (n=2,744). Cardiovascular biomarker screening (hsTnI, BNP, HCY) was evaluated on Proportion of individuals with biomarker levels indicative of moderate or high cardiovascular disease risk. Biomarker screening of a self-declared healthy Malaysian population identified moderate to high CVD risk based on hsTnI in up to 10% of participants, elevated BNP in 3.2%, and elevated homocysteine in over 50%.
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