Key result
9AC and DPC reversibly reduce transepithelial conductance and 36Cl rates to paracellular diffusion levels.
Why the study?
The pathways of chloride transport in rabbit cortical collecting tubule, specifically the roles of electroneutral versus conductive mechanisms, were not fully characterized.
Population
Rabbit cortical collecting tubule
Comparison
Anthracene-9-carboxylate (9AC, 1 mM) and diphenylamine carboxylate (DPC, 0.1-0.5 mM) versus baseline conditions
Design
Preclinical experimental study
Authors
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Reveals basolateral Cl conductance in rabbit CCT; extends renal transport models but leaves open human relevance.
Inhibitors of Cl conductance (9AC and DPC) reduce transepithelial conductance and Cl rate coefficient in rabbit cortical collecting tubules, suggesting a basolateral conductive pathway for transcellular Cl movement.
Tago et al. (1986) studied this question. Cl conductance inhibitors (anthracene-9-carboxylate and diphenylamine carboxylate) was evaluated on Transepithelial conductance (GT) and lumen-to-bath 36Cl rate coefficient (KCl). Anthracene-9-carboxylate and diphenylamine carboxylate reversibly reduced transepithelial conductance and the lumen-to-bath 36Cl rate coefficient to values consistent with paracellular diffusion.
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