Key result
HCO3 and CO2 acutely stimulate chloride exchange in rabbit tubules, chronically regulated by acid-base status.
Why the study?
The role of HCO3-CO2 in chloride transport and the effect of in vivo acid-base status on chloride transport by the rabbit cortical collecting tubule were not fully understood.
Population
Rabbit cortical collecting tubules from NaHCO3-loaded or NH4Cl-loaded rabbits
Comparison
HCO3-CO2-containing solutions vs HEPES-buffered (CO2-free) solutions
Design
Preclinical experimental study
Authors
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No direct clinical implications; extends mechanistic insights into acid-base regulation of rabbit tubular Cl transport.
This preclinical study demonstrates that chloride transport in the rabbit cortical collecting tubule is acutely stimulated by HCO3/CO2 and chronically regulated by in vivo acid-base status.
Tago et al. (1986) studied this question. HCO3-CO2 and in vivo acid-base status manipulation vs. HEPES-buffered (CO2-free) solutions was evaluated on Cl transport (rate coefficient KCl). Both Cl-HCO3 exchange and Cl self exchange in the rabbit cortical collecting tubule are acutely stimulated by HCO3 and/or CO2 and chronically regulated by in vivo acid-base status.
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