Primary Intramedullary Spinal Cord Astroblastoma with EWSR1/BEND2 Fusion: A Case Report and Literature Review

Astroblastomas are rare tumours of the central nervous system, and only a few cases of brain stem/primary spinal cord astroblastoma have been reported. It has been suggested that EWSR1/BEND2 fusion defines an epigenetically distinct subtype of astroblastoma. We present a rare case of primary intramedullary spinal cord astroblastoma with EWSR1/BEND2 fusion. To our knowledge, this is only the third reported case in the literature with this specific diagnosis, the first in an adult female, and the first that has been treated upfront with total surgical resection.