Key result
Exercise-induced troponin I elevation is seen only in muscle disease, suggesting severe sarcomeric damage.
Why the study?
Creatine kinase and myoglobin do not possess all good qualities as biomarkers of skeletal muscle damage, prompting investigation of troponin I and telethonin as alternative markers.
Does exercise induce changes in plasma troponin I and telethonin in patients with muscle disease compared to healthy subjects?
Observational
Does exercise induce changes in plasma troponin I and telethonin in patients with muscle disease compared to healthy subjects?
Troponin I may serve as a useful biomarker for severe sarcomeric skeletal muscle damage, supplementing CK and myoglobin, whereas telethonin is not useful.
Answers are grounded in this paper and cite their sources.
Post-exercise troponin I warrants myopathy evaluation; leaves open its role as sarcomeric damage marker pending prospective validation.
INTRODUCTION: Creatine kinase (CK) and myoglobin (Mb) do not possess all good qualities as biomarkers of skeletal muscle damage. We investigated the utility of troponin I (TnI) and telethonin (Tcap) as markers and examined their temporal profiles after skeletal muscle damage. METHODS: Plasma profiles were measured before and after exercise in 3 groups: subjects affected by either Becker muscular dystrophy or McArdle disease, and healthy subjects. RESULTS: Mb and TnI appeared early in the blood, and the increase of TnI was only observed in patients with muscle disease. The CK increase was more delayed in plasma. Tcap was not detectable at any time. CONCLUSIONS: Our results suggest that TnI is a marker of more severe damage signifying sarcomeric damage, and it could therefore be an important supplement to CK and Mb in clinical practice. Tcap is not useful as a marker for skeletal muscle damage.
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Dahlqvist et al. (2013) conducted an observational in Becker muscular dystrophy or McArdle disease. Exercise vs. Pre-exercise baseline and healthy controls was evaluated on Temporal profiles of troponin I (TnI) and telethonin (Tcap) after skeletal muscle damage. Exercise-induced increases in troponin I were observed only in patients with muscle disease, suggesting it is a marker of severe sarcomeric damage, while telethonin was not detectable.
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