Key result
hs-cTnT emerges as a promising biomarker for evaluating neonatal myocardial injury.
Why the study?
There is no suitable cardiac serum biomarker that can accurately reflect neonatal myocardial injury, and the clinical value of adult markers in neonates is low.
High-sensitivity cardiac troponin T is emerging as a potential biomarker for evaluating myocardial injury in neonates, despite physiological differences from adults.
In recent years, high-sensitivity cardiac troponin T (hs-cTnT) has been recognized as an effective marker for myocardial injury in adults and can be used to diagnose acute myocardial injury and predict major adverse cardiovascular events. It is the gold standard for the diagnosis of acute myocardial infarction in adults. Neonates are a special group, and due to the changes of various physiological processes during the perinatal period, many laboratory markers used in adults may have a low clinical value in neonates. So far, for example, there is still no suitable cardiac serum biomarker that can reflect the true condition of neonatal myocardial injury. In recent years, new breakthroughs have been made in the application of hs-cTnT in the field of neonates. In order to fully understand the role of hs-cTnT in neonatal diseases, this article reviews the research advances in the biological and physiological features of hs-cTnT and its application in neonates.
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Tie-Geng Li (2019) conducted a review in Neonatal diseases and myocardial injury. High-sensitivity cardiac troponin T (hs-cTnT) was evaluated. High-sensitivity cardiac troponin T (hs-cTnT) is emerging as a promising biomarker for evaluating myocardial injury in neonates, despite physiological differences from adults.
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