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September 17, 2026Neurological Research

Robot-assisted gait training in cerebral palsy: a GRADE-assessed systematic review and meta-analysis with trial sequential analysis

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Authors

AMAlzahra’a Al MatairiOAOmar AbuhashemBHBara M. Hammadeh

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Overview

Systematic review and meta-analysis reveals modest improvements in walking endurance and speed with robotic gait training in children with cerebral palsy, suggesting selective functional advantages.

Key Points

  • To assess the efficacy of robot-assisted gait training compared to conventional therapy on gait, balance, and gross motor function in children with cerebral palsy.
  • Conducted a systematic review and meta-analysis of 15 RCTs encompassing 542 children with cerebral palsy, with 14 trials contributing to the meta-analyses.
  • Evaluated trial evidence using the Cochrane ROB 2 tool and GRADE framework, pooling outcomes via fixed- or random-effects models alongside Trial Sequential Analysis (TSA).
  • No statistically significant differences occurred between groups for hip flexion/extension, GMFM-66, total GMFM, GMFM-88 Dimension D, stride length, walking speed, step width, or balance (all p > 0.05).
  • Robot-assisted gait training provided modest benefits over conventional therapy in the 6-minute walk test (MD 17.52 m, 95% CI 7.70 to 27.34), the 10-meter walk test (MD 0.11 m/s, 95% CI 0.05 to 0.17), and GMFM-88 Dimension E (SMD 0.30, 95% CI 0.05 to 0.54).
  • Trial Sequential Analysis confirmed firm evidence of benefit for the 6-minute walk test and GMFM-88 Dimension E, while evidence for Dimension D remained inconclusive due to insufficient information size.

Cite This Study

Matairi et al. (2026) studied this question.

synapsesocial.com/papers/6aabb6635f706d05830e4c47https://doi.org/10.1080/01616412.2026.2697005
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Robot-assisted Gait Training in Cerebral Palsy: A Systematic Review, Meta-analysis, and Trial Sequential Analysis of Randomized Controlled Trials (P10-8.011)2026
  2. 2Robot-Assisted Gait Training and Changes In Motor Function and Brain Activation In Children With Cerebral Palsy: Preliminary Findings From A Pilot Study.2026
  3. 3Overground Gait Training With a Wearable Robot in Children With Cerebral Palsy2024 · 39 citations
  4. 4Therapeutic Benefits of Robot-Assisted Gait Training in Individuals With Spinal Cord Injury: A Systematic Review and Meta-Analysis2026
  5. 5The feasibility and effect of robot-assisted gait training frequency on gait functions in children with cerebral palsy – A single blinded, randomized pilot study2024