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September 17, 2026Journal of Drug Delivery and TherapeuticsOpen Access

Combined lumbar plexus and sciatic blocks maintain hemodynamic stability during awake hemiarthroplasty in severe AS.

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Why the study?

Hip fracture surgery in patients with severe aortic stenosis and advanced heart failure presents a major anesthetic challenge due to risks of myocardial depression and hemodynamic instability with general or neuraxial anesthesia.

Comparison

Combined posterior lumbar plexus and subgluteal sciatic nerve blocks without sedation with low-dose norepinephrine infusion

Design

Case report

Key result

Combined posterior lumbar plexus and sciatic nerve blocks allowed successful awake bipolar hemiarthroplasty with preserved hemodynamic stability in a high-risk patient with severe aortic stenosis.

Authors

MAMohammad Eid AliAAAshraf ALakkad

Discussion

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Overview

May support regional anesthesia for hemodynamic stability in severe AS; leaves open need for prospective trials before wider use.

Key Points

  • To evaluate the hemodynamic safety and feasibility of combined posterior lumbar plexus and subgluteal sciatic nerve blocks for urgent hip fracture surgery in a patient with critical aortic stenosis and heart failure.
  • A 74-year-old male with end-stage ischemic cardiomyopathy (ejection fraction 21%), true severe low-flow low-gradient aortic stenosis, and multiple comorbidities required urgent bipolar hemiarthroplasty.
  • Anesthesia was achieved using combined posterior lumbar plexus and subgluteal sciatic nerve blocks without intravenous sedation, alongside invasive arterial pressure monitoring and low-dose norepinephrine infusion (80–240 μg/h).
  • The four-hour surgical procedure was completed while the patient remained fully awake, with estimated intraoperative blood loss under 700 mL.
  • Hemodynamic parameters remained stable throughout the operation, maintaining blood pressure near 100/60 mmHg and heart rate between 60 and 85 beats per minute under CRT-D pacing.

Study Design

Type

Case Report (n=1)

Structured PICO

P
Population
A 74-year-old man with severe ischemic cardiomyopathy and true severe low-flow low-gradient aortic stenosis undergoing urgent bipolar hemiarthroplasty.
I
Intervention
Combined posterior lumbar plexus and subgluteal sciatic nerve blocks without sedation, with low-dose norepinephrine infusion (80-240 μg/h).
O
Outcome
Hemodynamic stability during surgery

Combined posterior lumbar plexus and sciatic nerve blocks offer a viable anesthetic strategy to maintain hemodynamic stability in patients with severe aortic stenosis and advanced heart failure undergoing urgent hip surgery.

Cite This Study

Ali et al. (2026) conducted a case report in Severe low-flow low-gradient aortic stenosis and end-stage ischemic cardiomyopathy requiring hip fracture surgery (n=1). Combined posterior lumbar plexus and subgluteal sciatic nerve blocks was evaluated on Hemodynamic stability and successful completion of surgery. Combined posterior lumbar plexus and sciatic nerve blocks allowed successful awake bipolar hemiarthroplasty with preserved hemodynamic stability in a high-risk patient with severe aortic stenosis.

synapsesocial.com/papers/6aabb68c5f706d05830e5009https://doi.org/10.22270/jddt.v16i9.7985
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