What question did this study set out to answer?

To assess clinical and psychometric correlates of interictal burden measured by the MIBS-4 scale among prophylaxis-free patients presenting with episodic versus chronic migraine.

September 17, 2026BMC NeurologyOpen Access

Correlates of interictal burden in episodic and chronic migraine: associations with disability, sleep quality, anxiety, and depression

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Authors

OZORKUN ZORSU VSVasfiye Sezer

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Overview

Observational study finds headache frequency is the primary correlate of interictal burden in migraine patients, suggesting disease severity outweighs psychological factors.

Key Points

To assess clinical and psychometric correlates of interictal burden measured by the MIBS-4 scale among prophylaxis-free patients presenting with episodic versus chronic migraine.
Cross-sectional study evaluating 200 prophylaxis-free, first-admission patients diagnosed with migraine according to ICHD-3 criteria (n=100 chronic migraine, n=100 episodic migraine; mean age 27.67 ± 8.18 years; 72.5% female).
Administered MIBS-4, HIT-6, PSQI, GAD-7, and PHQ-9 questionnaires, recording attack frequency strictly as monthly headache days (MHDs).
Constructed two multivariable linear regression models applying HC3 robust standard errors to identify independent predictors of MIBS-4 variance.
Severe sleep disturbance occurred significantly more often in chronic migraine than episodic migraine (48/100 [48%] vs. 34/100 [34%]; p = 0.044), with poor sleep quality or severe disturbance affecting 93% of the total cohort.
Migraine type was the strongest independent predictor of MIBS-4 burden in Model A (B = 3.000, 95% CI [2.041, 3.960], β = 0.559, p < 0.001), while monthly headache days drove burden in Model B (B = 0.206, 95% CI [0.132, 0.279], β = 0.463, p < 0.001).
Multivariable models accounted for approximately one-third of interictal burden variance (Model A R² = 0.334; Model B R² = 0.312), while psychometric measures of depression, anxiety, and sleep lost independent statistical significance.

Cite This Study

ZORSU et al. (2026) studied this question.

synapsesocial.com/papers/6aabb6b55f706d05830e54d1 https://doi.org/10.1186/s12883-026-05373-8

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September 17, 2026BMC NeurologyOpen Access

Correlates of interictal burden in episodic and chronic migraine: associations with disability, sleep quality, anxiety, and depression

View Full Paper

Ask AI

Bookmark

Authors

OZORKUN ZORSU VSVasfiye Sezer

Discussion

Member takes

Overview

Observational study finds headache frequency is the primary correlate of interictal burden in migraine patients, suggesting disease severity outweighs psychological factors.

Key Points

To assess clinical and psychometric correlates of interictal burden measured by the MIBS-4 scale among prophylaxis-free patients presenting with episodic versus chronic migraine.
Cross-sectional study evaluating 200 prophylaxis-free, first-admission patients diagnosed with migraine according to ICHD-3 criteria (n=100 chronic migraine, n=100 episodic migraine; mean age 27.67 ± 8.18 years; 72.5% female).
Administered MIBS-4, HIT-6, PSQI, GAD-7, and PHQ-9 questionnaires, recording attack frequency strictly as monthly headache days (MHDs).
Constructed two multivariable linear regression models applying HC3 robust standard errors to identify independent predictors of MIBS-4 variance.
Severe sleep disturbance occurred significantly more often in chronic migraine than episodic migraine (48/100 [48%] vs. 34/100 [34%]; p = 0.044), with poor sleep quality or severe disturbance affecting 93% of the total cohort.
Migraine type was the strongest independent predictor of MIBS-4 burden in Model A (B = 3.000, 95% CI [2.041, 3.960], β = 0.559, p < 0.001), while monthly headache days drove burden in Model B (B = 0.206, 95% CI [0.132, 0.279], β = 0.463, p < 0.001).
Multivariable models accounted for approximately one-third of interictal burden variance (Model A R² = 0.334; Model B R² = 0.312), while psychometric measures of depression, anxiety, and sleep lost independent statistical significance.

Cite This Study

ZORSU et al. (2026) studied this question.

synapsesocial.com/papers/6aabb6b55f706d05830e54d1 https://doi.org/10.1186/s12883-026-05373-8

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