Key result
Sendai virus strains vary by up to ~1,000,000-fold in lethal and lung consolidation doses.
Why the study?
Sendai virus strains isolated from laboratory rodents vary in virulence and other biological properties, but the extent of this variation was not fully characterized.
Sendai virus strains prevailing in laboratory rodents exhibit significant heterogeneity in virulence and other biological properties.
May affect rodent model reproducibility; leaves open need for strain standardization in virology research.
The virulence of five Sendai virus strains (MN, Z, KN, Mol, and Hm) isolated from laboratory rodents was compared, using 3-week-old female Jcl-ICR mice. The virulence of the strains was Mol, MN, KN, Z, and Hm in decreasing order. The 50% lethal dose and 50% lung consolidation inducing dose of the highest virulent strain differed by the order of more than 10(3) and 10(6), respectively, from those of the lowest virulent one. Other properties such as the growth rate in LLC-MK2 cells, neuraminidase activities, and molecular weights of structural proteins also differed among the virus strains. These results indicate that Sendai virus prevailing in laboratory rodents is not homogenous with respect to virulence and some other properties.
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Yamaguchi et al. (1988) studied Sendai virus infection. Sendai virus strains (MN, Z, KN, Mol, and Hm) vs. Between-strain comparison was evaluated on Virulence (50% lethal dose and 50% lung consolidation inducing dose). The virulence of five Sendai virus strains varied significantly, with the 50% lethal dose and 50% lung consolidation inducing dose differing by more than 10^3 and 10^6 between the highest and lowest.
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