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September 17, 2026BJC ReportsOpen Access

Immune remodeling and myeloid signature in the bone marrow niche of MYCN-driven neuroblastoma

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Authors

BEBethel Tesfai EmbaieAAAdele M. AlchahinLVLilly Velentza

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Overview

Preclinical study reveals bone marrow immune remodeling and myeloid expansion in MYCN-driven neuroblastoma mice, highlighting FABP4-positive macrophages as potential immunotherapeutic targets.

Key Points

  • To determine how MYCN-amplified neuroblastoma systemically alters the bone marrow niche and remodels resident immune cell populations.
  • Profiled the bone marrow immune microenvironment using single-cell RNA sequencing to compare wild-type and TH-MYCN transgenic mice.
  • Conducted ligand-receptor interaction analyses to map altered signaling pathways and compared mouse profiles with human neuroblastoma bone marrow metastasis datasets.
  • TH-MYCN mice exhibited higher levels of neutrophils and Cd300e+ myeloid cells alongside a reduction in developing B cells, mirroring human bone marrow metastasis profiles.
  • Ligand-receptor profiling revealed marked enrichment of ADGRG and SEMA4 signaling pathways (including Tgm2-Adgrg1 and Sema4D-Plxnb2) in TH-MYCN bone marrow compared to CD45 and CEACAM pathways in controls.
  • Identified an enriched Cd300e+ Pecam1+ myeloid population expressing Fabp4, Ear2, and Treml4, consistent with pro-metastatic FABP4+ macrophages linked to relapse and reduced survival.

Cite This Study

Embaie et al. (2026) studied this question.

synapsesocial.com/papers/6aabb6f95f706d05830e5bbchttps://doi.org/10.1038/s44276-026-00249-3
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Single-cell analyses of metastatic bone marrow in human neuroblastoma reveals microenvironmental remodeling and metastatic signature2024 · 17 citations
  2. 2Integrated Genomic and Proteomic Analysis Reveals T‐B Lymphocyte Signatures in the MYCN Driven “Immune Desert” of Specific Neuroblastoma Subtypes2026
  3. 3Single-cell transcriptomics reveals shared immunosuppressive landscapes of mouse and human neuroblastoma2022 · 58 citations
  4. 4Abstract 639: Distinct microenvironments define subtypes of neuroblastoma.2026
  5. 5Comparative Study of Single-Cell and Bulk RNA Sequencing Data from Metastatic Bone Marrow Neuroblastoma Samples2026