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September 17, 2026TrialsOpen Access

Efficacy of simultaneous aerobic exercise and cognitive training in persons with subjective cognitive decline residing in Minnesota: study protocol for randomized controlled trial of the Exergames TeleHealth Study

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Authors

DSDereck SalisburyUniversity of MinnesotaOOOlu OlafinbobaMMMichelle Mathiason

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Overview

Randomized superiority trial evaluates home-based exergaming combining aerobic exercise and cognitive training in subjective cognitive decline, suggesting a scalable strategy to prevent dementia.

Key Points

  • To evaluate the usability, user satisfaction, and efficacy of an asynchronous, home-based exergaming intervention on cognition, cardiorespiratory fitness, and biomarkers in older adults with subjective cognitive decline.
  • Single-blinded, 2-parallel group superiority randomized controlled trial enrolling 104 community-dwelling older adults (aged ≥65 years) with subjective cognitive decline (NCT06340659).
  • Participants are stratified by age (65–74 and ≥75 years) and randomized 1:1 using permuted blocks of 8 and 4 to 3 months of home-based BrainFitRx exergaming or home-based aerobic exercise.
  • Primary and secondary outcomes will be evaluated via analysis of covariance under an intention-to-treat framework.
  • The protocol defines primary endpoints as usability, user satisfaction, and cognitive performance measured across a 3-month intervention period.
  • Secondary endpoints assess cardiorespiratory fitness along with neuroprotective and neuro/systemic inflammatory biomarkers to establish effect-size estimates for future dementia prevention trials.

Cite This Study

Salisbury et al. (2026) studied this question.

synapsesocial.com/papers/6aabb74e5f706d05830e63cchttps://doi.org/10.1186/s13063-026-09986-9
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Effects of Exergame Telerehabilitation in Persons With Subjective Cognitive Decline2024 · 4 citations
  2. 2Exercise Telehealth in Rural-Dwelling Adults with Subjective Cognitive Decline: The MN RIDE Pilot Study2024
  3. 3Exergame as medicine? Functional brain adaptations linked to cognitive changes in neurocognitive disorders: exploratory randomized controlled trial2026
  4. 4Home-based EXergames To impRovE cognitive function in MUltiple Sclerosis (EXTREMUS)2025
  5. 5Effects of Web-Based Physical–Cognitive Telerehabilitation Exergaming on Physical and Cognitive Performance in Chronic Stroke Survivors: Protocol for a Randomized Controlled Trial2026