Retrospective cohort study finds no correlation between beta-hydroxybutyrate levels and myocardial glucose suppression in suspected cardiac sarcoidosis, suggesting a ketosis threshold effect.
This retrospective cohort study evaluated the relationship between serum β-hydroxybutyrate (BHB) levels and myocardial glucose suppression in 74 patients undergoing 18F-FDG PET/CT for suspected cardiac sarcoidosis. The average BHB concentration prior to FDG administration was 0.94 ± 0.78 mmol/L. The septal-to-blood pool uptake ratio (SUVmax_septal/SUVmean_blood pool) ranged from 0.50 to 0.88, with a median of 0.66 (Quartile 1 = 0.58, Quartile 3 = 0.73). No significant association was found between BHB levels and the septal-to-blood pool uptake ratio (r = 0.09, p = 0.48), suggesting a metabolic plateau regarding myocardial glucose utilization once adequate ketosis is achieved. These preliminary findings support a threshold effect rather than a dose-dependent relationship between serum BHB levels and myocardial glucose suppression following appropriate dietary preparation.
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Harake et al. (2026) studied this question.
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