What does this research mean for the field?

A prolonged 72-hour high-fat, high-protein, very-low-carbohydrate diet prior to FDG-PET/CT successfully suppresses physiological myocardial FDG uptake and significantly reduces indeterminate scan rates in patients with suspected cardiac sarcoidosis. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate whether a prolonged high-fat, high-protein, and very-low-carbohydrate diet can suppress myocardial FDG uptake in patients evaluated for cardiac sarcoidosis.

December 6, 2016Clinical Nuclear Medicine

Suppression of Myocardial 18F-FDG Uptake Through Prolonged High-Fat, High-Protein, and Very-Low-Carbohydrate Diet Before FDG-PET/CT for Evaluation of Patients With Suspected Cardiac Sarcoidosis

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Why the study?

Does a prolonged 72-hour high-fat, high-protein, and very-low-carbohydrate diet reduce indeterminate myocardial FDG uptake in patients with suspected cardiac sarcoidosis undergoing FDG-PET/CT?

Key Points

To evaluate whether a prolonged high-fat, high-protein, and very-low-carbohydrate diet can suppress myocardial FDG uptake in patients evaluated for cardiac sarcoidosis.
Retrospective study of 215 FDG-PET/CT tests from 207 patients with suspected cardiac sarcoidosis.
Patients categorized into two groups based on diet preparation duration prior to FDG-PET/CT: ≤24 hours or 72 hours.
FDG uptake classified as negative, positive, or indeterminate for cardiac sarcoidosis.
In group 1 (short diet preparation), 8.3% tested positive for cardiac sarcoidosis.
In group 2 (72-hour diet), 9.8% tested positive for cardiac sarcoidosis, with a significantly lower indeterminate rate (P < 0.001).
The SUVmax of positive myocardial lesions ranged from 3.4 to 12.5, compared to a mediastinal blood pool SUVmean of 1.1 to 3.6.

Structured PICO

Does a prolonged 72-hour high-fat, high-protein, and very-low-carbohydrate diet reduce indeterminate myocardial FDG uptake in patients with suspected cardiac sarcoidosis undergoing FDG-PET/CT?

Population

207 patients with biopsy-proven sarcoidosis and clinical suspicion for cardiac sarcoidosis undergoing 215 FDG-PET/CT tests

Intervention

72-hour pretest high-fat, high-protein, and very-low-carbohydrate (HFHPVLC) diet preparation

Comparator

24-hour or less pretest HFHPVLC diet preparation

Outcome

Rate of indeterminate cardiac FDG uptake (diffuse uptake)surrogate

A prolonged 72-hour high-fat, high-protein, very-low-carbohydrate diet significantly reduces indeterminate physiological myocardial FDG uptake, improving the diagnostic accuracy of FDG-PET/CT for cardiac sarcoidosis.

Authors

YLYang LüDalian Medical University CGChristopher GrantMedical College of Wisconsin KXKaren L. XieRush University Medical Center

Discussion

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Implication

May support 72-hour diet to reduce indeterminate FDG-PET scans in suspected cardiac sarcoidosis; leaves open randomized confirmation before practice change.

Cite This Study

Lü et al. (2016) studied this question.

synapsesocial.com/papers/6a1bc6c55b8f4ede65a90230 https://doi.org/10.1097/rlu.0000000000001465

Topics

Cardiomyopathy

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Implication

May support 72-hour diet to reduce indeterminate FDG-PET scans in suspected cardiac sarcoidosis; leaves open randomized confirmation before practice change.

Suppression of Myocardial 18F-FDG Uptake Through Prolonged High-Fat, High-Protein, and Very-Low-Carbohydrate Diet Before FDG-PET/CT for Evaluation of Patients With Suspected Cardiac Sarcoidosis

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Topics

Suppression of Myocardial 18F-FDG Uptake Through Prolonged High-Fat, High-Protein, and Very-Low-Carbohydrate Diet Before FDG-PET/CT for Evaluation of Patients With Suspected Cardiac Sarcoidosis

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

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