Key result
An 18-hour fast combined with a low-carbohydrate diet preparation significantly reduced the incidence of diffuse physiological left ventricular FDG uptake compared to a 6-hour fast (0.0% vs 27.6%, p=0.0041).
Why the study?
Does an 18-hour fast with a low-carbohydrate diet reduce physiological diffuse LV FDG uptake compared to a 6-hour fast in patients with suspected cardiac sarcoidosis?
Population
82 patients with suspected cardiac involvement sarcoidosis who underwent FDG PET or PET/CT, mean age 54.1 ±…
Comparison
Minimum 18-hour fasting with low-carbohydrate… vs Minimum 6-hour fasting without low-carbohydrate…
Design
Cohort, Two nuclear medicine physicians blinded to clinical and other test…
Authors
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May reduce physiological LV FDG uptake on cardiac PET; hypothesis-generating and requires randomized confirmation.
Cohort (n=82)
Single-blind
None
No
Does an 18-hour fast with a low-carbohydrate diet reduce physiological diffuse LV FDG uptake compared to a 6-hour fast in patients with suspected cardiac sarcoidosis?
Absolute Event Rate: 0% vs 27.6%
p-value: p=0.0041
An 18-hour fast combined with a low-carbohydrate diet effectively suppresses physiological myocardial FDG uptake in patients undergoing PET imaging for suspected cardiac sarcoidosis, whereas heparin administration does not appear to significantly reduce this uptake.
Manabe et al. (2015) conducted a cohort in Suspected cardiac involvement sarcoidosis (n=82). 18-hour fasting with low-carbohydrate diet vs. Minimum 6-hour fasting without low-carbohydrate diet was evaluated on Diffuse left ventricular FDG uptake (p=0.0041). An 18-hour fast combined with a low-carbohydrate diet preparation significantly reduced the incidence of diffuse physiological left ventricular FDG uptake compared to a 6-hour fast (0.0% vs 27.6%, p=0.0041).
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