Key result
Genetic and MRI testing reclassifies suspected COVID-19 vaccine myocarditis as arrhythmogenic cardiomyopathy.
Why the study?
Reports of mild and self-limited myocarditis post-COVID-19 vaccination may obscure underlying cardiac conditions and cause diagnostic challenges.
Case Report (n=1)
Highlights the importance of thorough diagnostic work-up to differentiate underlying genetic cardiomyopathies from vaccine-associated myocarditis.
Answers are grounded in this paper and cite their sources.
May warrant genetic evaluation and serial MRI before attributing myocarditis to vaccination; leaves open arrhythmogenic cardiomyopathy as key differential in adolescents.
A 15-year-old male presented with vasovagal syncope and troponin leak 4 days after his second COVID-19 vaccine. Based on initial diagnostic work-up, he was thought to have COVID-19 vaccine-associated myocarditis. His cardiac dysfunction persisted and further work-up including genetic evaluation and serial MRI studies later confirmed a diagnosis of arrhythmogenic cardiomyopathy. This is a unique case of an incorrect diagnosis based on timing and context of vaccine-related myocarditis. Reports of mild and self-limited myocarditis post-COVID-19 vaccination may cause vaccine hesitancy among the public, and so case reports such as this one show the importance of discerning underlying conditions amongst rare COVID-19 vaccination complications.
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Perry et al. (2025) conducted a case report in Arrhythmogenic cardiomyopathy (n=1). COVID-19 vaccine was evaluated. A 15-year-old male's suspected COVID-19 vaccine-associated myocarditis was ultimately diagnosed as arrhythmogenic cardiomyopathy following genetic evaluation and serial MRI studies.
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