Clinical report demonstrates a pragmatic management approach using provocative testing in high-altitude travelers with sulfonamide allergy, suggesting safer clinical decision-making.
Highlight Managing high-altitude travelers with self-reported sulfonamide allergy is challenging. History of severe allergies are managed conservatively, while those with non-severe allergies to antimicrobial sulfonamides may receive acetazolamide. Uncertain histories remain problematic. We describe a pragmatic real-world approach, including acetazolamide provocative testing, to support clinical decision-making.
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Charoensakulchai et al. (2026) studied this question.
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