Key result
MDCT screening reveals mostly non-significant CAD in ~68% of asymptomatic middle-aged adults.
Why the study?
The prevalence of coronary artery disease in asymptomatic subjects and its relationship to demographic and clinical risk factors was not well characterized using multidetector computed tomography.
What is the prevalence of coronary artery disease detected by MDCT in an asymptomatic population?
Cross-Sectional (n=188)
No
What is the prevalence of coronary artery disease detected by MDCT in an asymptomatic population?
MDCT screening in middle-aged asymptomatic individuals reveals a high prevalence of non-significant CAD and a low prevalence of significant CAD, particularly in males and those with multiple risk factors.
MDCT-detected CAD prevalence in asymptomatic adults should not change screening practice; leaves open prognostic value of non-significant lesions.
AIM: To assess the prevalence of coronary artery disease (CAD) in asymptomatic subjects using multidetector computed tomography (MDCT) and its relationships to demographic and clinical risk factors. MATERIAL AND METHOD: We enrolled consecutive asymptomatic volunteers with no evidence of ischemic heart disease that underwent MDCT for the early detection of CAD. All MDCT findings were correlated with demographic and risk factors. A total of 2820 coronary segments were analyzed in 188 asymptomatic subjects (150 males and 38 females), aged 54.4 +/- 7.4 years. RESULTS: A total of 128 (68%) demonstrated MDCT findings compatible with CAD; of these 111 (86.7%) had non-significant (diameter stenosis </= 50%) and 17 (13.3%) had significant CAD (diameter stenosis >/= 50%). Compared with older subjects (mean age 56+/-8 years), younger subjects had a lower prevalence of MDCT findings of CAD 55.5% vs. 12.5%, respectively (P<0.001), regardless of risk factors. Males had more CAD (mostly non-significant) compared with females (109 [72.7%] vs. 19 [50.3%], respectively; P= 0.007). Subjects with >/= 2 risk factors had a higher prevalence of CAD in general and significant CAD in particular (P<0.001). CONCLUSION: CAD in asymptomatic population seems to be not uncommon. Using MDCT a high prevalence of non-significant and low prevalence of significant CAD was discovered in middle age asymptomatic population.
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Zaid et al. (2010) conducted a cross-sectional in Asymptomatic subjects without ischemic heart disease (n=188). Multidetector computed tomography (MDCT) coronary angiography was evaluated on Prevalence of coronary artery disease (CAD). In an asymptomatic middle-aged population, MDCT screening detected a 68% prevalence of coronary artery disease, with 86.7% of these cases being non-significant and 13.3% significant.
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