What question did this study set out to answer?

To assess the prognostic impact and therapeutic efficacy of chemotherapy, particularly platinum-containing regimens, on patient survival in extraskeletal osteosarcoma.

June 15, 2017American Journal of Clinical OncologyOpen Access

Extraskeletal Osteosarcoma

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Authors

JPJonas PaludoMayo Clinic KFKaren FritchieCleveland Clinic CHCandace L. HaddoxHarvard University

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Implication

Cohort study reveals improved survival with platinum-based chemotherapy in extraskeletal osteosarcoma, indicating a distinct clinical benefit over other regimens.

Key Points

To assess the prognostic impact and therapeutic efficacy of chemotherapy, particularly platinum-containing regimens, on patient survival in extraskeletal osteosarcoma.
Retrospective cohort study evaluating N=43 patients diagnosed with extraskeletal osteosarcoma at Mayo Clinic between 1990 and 2014.
Archived pathology slides were comprehensively re-examined to confirm diagnosis across 37 localized and 6 metastatic presentations.
Patients receiving platinum-based chemotherapy exhibited markedly longer median overall survival compared to nonplatinum regimens (182 vs. 18 months; 5-year OS, 61% vs. 0%; P=0.01).
Progression-free survival was significantly superior in the platinum cohort compared to the nonplatinum cohort (median, not reached vs. 10 months; 5-year PFS, 56% vs. 0%; P=0.005).
Relapse and recurrence rates among chemotherapy-treated individuals were 41% with platinum agents versus 100% with nonplatinum alternatives (P=0.02), accompanied by a 27% neoadjuvant response rate.

Cite This Study

Paludo et al. (2017) studied this question.

synapsesocial.com/papers/6aabbcba3f7780684316de46 https://doi.org/10.1097/coc.0000000000000397

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Implication

Cohort study reveals improved survival with platinum-based chemotherapy in extraskeletal osteosarcoma, indicating a distinct clinical benefit over other regimens.

Extraskeletal Osteosarcoma

Discussion

Member takes

Implication

Key Points

Cite This Study

Extraskeletal Osteosarcoma

Discussion

Member takes

Implication

Key Points

Cite This Study

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