What question did this study set out to answer?

To develop a tumor microenvironment-responsive nanoboron platform that mitigates immunosuppression and amplifies the therapeutic efficacy of boron neutron capture therapy.

December 20, 2025Journal of NanobiotechnologyOpen Access

Manganese-enriched nanoboron agent amplifies BNCT efficacy via pyroptosis-mediated immune activation and STING pathway synergy

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Authors

ZZZhicheng ZhangAnhui Medical University XSXiaoyan SunZhejiang Province Institute of Architectural Design and Research YQYaxin QinZhejiang University

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Implication

Preclinical evaluation demonstrates enhanced tumor suppression and systemic immunity in melanoma models, highlighting a responsive nanoplatform for immune-integrated boron neutron capture therapy.

Key Points

To develop a tumor microenvironment-responsive nanoboron platform that mitigates immunosuppression and amplifies the therapeutic efficacy of boron neutron capture therapy.
Engineered BSA-BPA-MnO2 nanoparticles combining boron delivery with manganese-driven Fenton-like catalytic activity and magnetic resonance imaging contrast.
Assessed oxidative stress induction, cGAS-STING pathway signaling, and immunogenic pyroptosis in cellular models.
Evaluated dendritic cell maturation, CD8+ T-cell immune responses, and tumor suppression in melanoma models using subclinical boron doses.
BSA-BPA-MnO2 catalyzed local reactive oxygen species production and induced immunogenic pyroptosis along with robust type I interferon signaling.
Treatment promoted dendritic cell maturation and potent CD8+ T-cell mediated antitumor responses, maintaining significant tumor suppression at subclinical boron levels.
Nanoparticle-integrated MnO2 provided concurrent magnetic resonance imaging contrast, enabling image-guided therapeutic monitoring.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/6aabc1761bb6b918d8ca36f2 https://doi.org/10.1186/s12951-025-03916-8

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Implication

Preclinical evaluation demonstrates enhanced tumor suppression and systemic immunity in melanoma models, highlighting a responsive nanoplatform for immune-integrated boron neutron capture therapy.

Manganese-enriched nanoboron agent amplifies BNCT efficacy via pyroptosis-mediated immune activation and STING pathway synergy

Discussion

Member takes

Implication

Key Points

Cite This Study

Manganese-enriched nanoboron agent amplifies BNCT efficacy via pyroptosis-mediated immune activation and STING pathway synergy

Discussion

Member takes

Implication

Key Points

Cite This Study

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