What is the clinical evidence from this study?

Study design: Other. Intervention: Three-stage alcohol clamp procedure. Primary outcome: Correlation between blood alcohol levels and breath alcohol levels (r= 0.96, p=< 0.001).

What does this research mean for the field?

A three-stage intravenous alcohol clamp procedure guided by a pharmacokinetic model achieves sequential steady-state blood alcohol levels of 50, 100, and 150 mg/dl with less than 5% deviation. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

October 1, 2002Alcoholism Clinical and Experimental Research

Intravenous alcohol clamp achieves target blood levels with <5% deviation, correlating strongly with breath levels.

Q: What are the key findings of this study?

A three-stage intravenous alcohol clamp procedure successfully achieved target blood alcohol levels with <5% deviation, showing a strong correlation with breath alcohol levels (r=0.96; p<0.001).

Q: What does this research mean for the field?

A three-stage intravenous alcohol clamp procedure guided by a pharmacokinetic model achieves sequential steady-state blood alcohol levels of 50, 100, and 150 mg/dl with less than 5% deviation. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

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Population

5 human subjects

Design

Other

Key result

A three-stage intravenous alcohol clamp procedure successfully achieved target blood alcohol levels with <5% deviation, showing a strong correlation with breath alcohol levels (r=0.96; p<0.001).

Authors

MSMarappa G. Subramanian SHSarah H. Heil MKMichael Krüger

Discussion

Member takes

Overview

Validates precise alcohol clamping for experimental research; leaves open translation to clinical or CV settings.

Structured PICO

Population

5 human subjects undergoing a three-stage intravenous alcohol clamp procedure.

Intervention

Intravenous infusion of 6% alcohol in saline to achieve sequentially increasing steady-state blood alcohol levels (BALs) at 50, 100, and 150 mg/dl

Outcome

Achievement and maintenance of target steady-state blood alcohol levels (50, 100, and 150 mg/dl) and measurement variationssurrogate

Main Result

Effect estimate: r= 0.96

p-value: p=< 0.001

A three-stage intravenous alcohol clamp procedure successfully achieved and maintained target steady-state blood alcohol levels with less than 5% deviation.

Cite This Study

Subramanian et al. (2002) studied this question. Three-stage alcohol clamp procedure was evaluated on Correlation between blood alcohol levels and breath alcohol levels (r= 0.96, p=< 0.001). A three-stage intravenous alcohol clamp procedure successfully achieved target blood alcohol levels with <5% deviation, showing a strong correlation with breath alcohol levels (r=0.96; p<0.001).

synapsesocial.com/papers/6aabc2de6987e115f8c53ee7 https://doi.org/10.1097/00000374-200210000-00004

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October 1, 2002Alcoholism Clinical and Experimental Research

Intravenous alcohol clamp achieves target blood levels with <5% deviation, correlating strongly with breath levels.

View Full Paper

Ask AI

Bookmark

Population

5 human subjects

Design

Other

Key result

A three-stage intravenous alcohol clamp procedure successfully achieved target blood alcohol levels with <5% deviation, showing a strong correlation with breath alcohol levels (r=0.96; p<0.001).

Authors

MSMarappa G. Subramanian SHSarah H. Heil MKMichael Krüger

Discussion

Member takes

Overview

Validates precise alcohol clamping for experimental research; leaves open translation to clinical or CV settings.

Structured PICO

Population

5 human subjects undergoing a three-stage intravenous alcohol clamp procedure.

Intervention

Intravenous infusion of 6% alcohol in saline to achieve sequentially increasing steady-state blood alcohol levels (BALs) at 50, 100, and 150 mg/dl

Outcome

Achievement and maintenance of target steady-state blood alcohol levels (50, 100, and 150 mg/dl) and measurement variationssurrogate

Main Result

Effect estimate: r= 0.96

p-value: p=< 0.001

A three-stage intravenous alcohol clamp procedure successfully achieved and maintained target steady-state blood alcohol levels with less than 5% deviation.

Cite This Study

synapsesocial.com/papers/6aabc2de6987e115f8c53ee7 https://doi.org/10.1097/00000374-200210000-00004

Also Consider

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