Key result
T2D and HF in men linked to 13 downregulated serum miRNAs regulating angiogenesis and apoptosis.
Why the study?
Diabetic patients have an increased risk for heart failure independently of CAD and hypertension, but little is known about circulatory miRNA in this population.
Case-Control (n=9)
No
p-value: p=<0.05
Diabetic patients with heart failure exhibit significant downregulation of 13 specific serum miRNAs, including miRNA-15b-5p, which are involved in angiogenesis and apoptosis.
Should not yet inform clinical decisions in diabetic HF; leaves open miRNA roles in angiogenesis/apoptosis for prospective validation.
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Wrzosek et al. (2022) conducted a case-control in Type 2 diabetes mellitus and heart failure (n=9). Heart failure and type 2 diabetes mellitus vs. Healthy controls was evaluated on Differential accumulation of serum miRNAs (p=<0.05). In male patients with type 2 diabetes and heart failure, 13 serum miRNAs were significantly downregulated compared to healthy controls, regulating pathways involved in angiogenesis and apoptosis.
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