Key result
Perioperative chemotherapy with conservative surgery achieves ~65% cure rates for localized osteosarcoma versus historical amputation.
Why the study?
Osteosarcoma is a rare highly malignant primary bone tumour with historically poor cure rates, and current treatment outcomes with chemotherapy and surgery need summarizing.
Does pre- and postoperative chemotherapy associated with surgery improve cure rates in patients with osteosarcoma compared to historical amputation?
Population
Patients with osteosarcoma, age 10 to 25 years
Comparison
Pre- and postoperative chemotherapy with surgery versus historical amputation treatment
Design
Review
Authors
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May support chemotherapy with conservative surgery in localized osteosarcoma; leaves open randomized confirmation versus amputation.
Does pre- and postoperative chemotherapy associated with surgery improve cure rates in patients with osteosarcoma compared to historical amputation?
Modern treatment of osteosarcoma with chemotherapy and limb-salvage surgery has dramatically improved cure rates from under 10% to 60-70% for localized disease.
Piero Picci (2007) conducted a review in Osteosarcoma. Pre- and postoperative chemotherapy associated with surgery vs. Amputation (historical) was evaluated on Cure rate. Pre- and postoperative chemotherapy with conservative surgery for localized osteosarcoma achieves cure rates of 60-70%, compared to historical cure rates under 10% with amputation alone.
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