Key result
Myocardial collagen degradation explains ~85% of sRVEF variance in patients with D-TGA.
Why the study?
Heart failure is a serious event in patients with transposition of the great arteries after atrial redirection surgery, and the association between myocardial fibrosis and systemic right ventricle dysfunction needed clarification.
Population
48 patients with atrially switched D-TGA and 26 healthy subjects
Comparison
Patients with atrially switched D-TGA vs healthy subjects
Design
Prospective cross-sectional study using echocardiography and cardiac magnetic resonance imaging
Authors
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Myocardial fibrosis may associate with sRV dysfunction in D-TGA; leaves open causal links and need for longitudinal imaging studies.
Cross-Sectional (n=74)
Effect estimate: R2 = 0.85
p-value: p=<0.01
In patients with D-TGA after atrial switch, systemic right ventricular dysfunction is strongly associated with myocardial collagen degradation and fibrosis, suggesting a potential therapeutic target.
Ladouceur et al. (2018) conducted a cross-sectional in Transposition of the great arteries (D-TGA) after atrial switch (n=74). Myocardial fibrosis and collagen degradation vs. Healthy subjects / lower fibrosis levels was evaluated on Systemic right ventricular ejection fraction (sRVEF) (R2 = 0.85, p=<0.01). Myocardial collagen degradation, measured by the pro-MMP1:TIMP1 ratio, was the strongest determinant of systemic right ventricular ejection fraction in patients with D-TGA (R2=0.85, p<0.01).
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