Key result
Conservative surgery for young synovial sarcoma achieves ~72% five-year EFS, influenced by tumor invasiveness.
Why the study?
A contemporary multi-centre analysis of synovial sarcoma in children and young people was needed to describe clinical characteristics, prognostic factors, and outcomes with emphasis on conservative treatment for localized disease.
Does a conservative approach (surgery only) provide favorable outcomes in young patients with small completely resected synovial sarcoma?
Population
77 young patients with synovial sarcoma registered or treated by the Children's Cancer and Leukaemia Group between 1991 and 2006
Comparison
Surgery only for localized favourable disease versus other treatments
Design
Retrospective multi-centre cohort study
Authors
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May inform risk stratification by tumor size and invasiveness in young synovial sarcoma patients; leaves open prospective validation of therapy.
Cohort (n=77)
Yes
Does a conservative approach (surgery only) provide favorable outcomes in young patients with small completely resected synovial sarcoma?
A conservative approach of surgery alone is valid for young patients with small completely resected synovial sarcomas.
Brennan et al. (2010) conducted a cohort in Synovial sarcoma (n=77). Conservative approach (surgery only) was evaluated on Five-year event-free survival (EFS) and overall survival (OS). Among 77 young patients with synovial sarcoma, 5-year event-free survival was 72% and overall survival was 76%, with survival significantly influenced by tumour invasiveness and size.
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