Key result
Cloning uaf-1 in C. elegans reveals a novel alternatively spliced RNA that accumulates during starvation.
Why the study?
Caenorhabditis elegans introns lack typical polypyrimidine tract and branch point consensus sequences, raising uncertainty about U2AF's role in intron recognition in this species.
Population
Caenorhabditis elegans and Caenorhabditis briggsae nematodes
Comparison
Alternative splicing variants of uaf-1 gene including novel exon vs canonical transcript
Design
Gene cloning and sequencing study
Authors
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Hypothesis-generating for starvation-responsive splicing in nematodes; leaves open conservation and relevance to mammalian U2AF regulation.
The cloning of uaf-1 in C. elegans reveals an alternatively spliced RNA that accumulates during starvation, suggesting a regulatory role in modulating U2AF65 levels.
Zorio et al. (1997) studied this question. Cloning of the uaf-1 gene in C. elegans revealed an alternatively spliced RNA containing a novel exon with multiple 3' splice site consensus matches that accumulates during starvation.
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