Extraction of Chondroitin Sulfate from Tilapia Byproducts with Ultrasonic-Microwave Synergistic

The optimum conditions for the extraction and separation of chondroitin sulfate from tilapia (Oreochromis niloticus) byproducts were studied in the paper. The chondroitin sulfate was extracted by the combination of ultrasonic and microwave. On the basis of the single factor tests, the response surface methodology was taken to study the optimum process of extraction. Results show that the best conditions for the extraction and separation of chondroitin sulfate from tilapia byproducts are: the ultrasonic power is 50W, the microwave power is 98W, the extraction time is 120s, the ratio of solid to liquid is 1:50 (g/mL), and under these conditions, the extraction rate of chondroitin sulfate is 2.513%.