Cystic Fibrosis in Female Gender

Introduction: Cystic fibrosis (CF) is a lethal autosomal recessive disease.It has been reported that females are diagnosed later than males (2) and have a significantly decreased survival.Methods: Clinical trials were identified by PubMed until June 30 2020.The search keywords were "sex, gender differences, cystic fibrosis".Result: It has been suggested, that cystic fibrosis is diagnosed later in female children, because underdiagnosed.Unfortunately, cystic fibrosis determines airway inflammation and chronic respiratory infection, such as Pseudomonas aeruginosa.Different factors are related to these inflammations.However, mortality and cystic fibrosis-related diabetes (CFRD) prevalence were higher, in female subjects than males.Conclusion: Female subjects have significantly higher mortality than males, with about 4-year difference in median survival.However, adolescent girls with CF have a greater emotional impact compared to boy.