Key result
Native Arp1 rapidly polymerizes into short filaments but fails to reach conventional actin length.
Why the study?
The assembly mechanism and polymerization behavior of the actin-related protein Arp1, a major dynactin subunit, were not fully understood.
Design
Analysis of highly purified native Arp1 protein polymerization behavior
Authors
Loading...
Arp1's ATP-binding and oligomerization potential may extend models of dynactin assembly; leaves open functional roles in dynein motors for targeted studies.
Bingham et al. (1999) studied this question. Highly purified, native Arp1 was evaluated on Polymerization behavior. Highly purified, native Arp1 polymerized rapidly into short filaments that annealed over time but never attained the length of conventional actin filaments.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: