What question did this study set out to answer?

To evaluate the relative reliability of five serially measured serum tumor markers for predicting clinical disease progression in patients with prostate cancer.

February 1, 1986JNCI Journal of the National Cancer Institute

Relative Reliability of Five Serially Measured Markers for Prognosis of Progression in Prostate Cancer 2 3

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Authors

CKC. S. KillianRoswell Park Comprehensive Cancer Center LELawrence J. EmrichGynecologic Oncology Group YNYang NaSeoul National University

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Implication

Cohort study reveals serial prostate-specific antigen outperforms other markers in predicting prostate cancer progression, indicating its superior clinical utility for monitoring disease.

Key Points

To evaluate the relative reliability of five serially measured serum tumor markers for predicting clinical disease progression in patients with prostate cancer.
Analyzed 1,065 serial serum specimens collected over an 8-year period from 130 patients, categorized into stage B2 to D1 (group I, N=79) and stage D2 (group II, N=51).
Evaluated acid phosphatase, total alkaline phosphatase, bone alkaline phosphatase, prostatic acid phosphatase, and prostate-specific antigen using Gail's modification of Cox's regression model.
Prostate-specific antigen (PA) was the most significant predictor of disease progression in both group I (P = .0052) and group II (P < .0001).
Elevated PA levels predicted disease progression 6 months prior to clinical manifestation in group I patients (P < .0001).
Multivariate analyses showed that after adjusting for PA, no other marker was significantly associated with progression risk, establishing a reliability hierarchy of PA > PAP > BAP > AcP > TAP.

Cite This Study

Killian et al. (1986) studied this question.

synapsesocial.com/papers/6aabd2e1c12b6ee7d716ea8b https://doi.org/10.1093/jnci/76.2.179

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Implication

Cohort study reveals serial prostate-specific antigen outperforms other markers in predicting prostate cancer progression, indicating its superior clinical utility for monitoring disease.

Relative Reliability of Five Serially Measured Markers for Prognosis of Progression in Prostate Cancer 2 3

Discussion

Member takes

Implication

Key Points

Cite This Study

Relative Reliability of Five Serially Measured Markers for Prognosis of Progression in Prostate Cancer 2 3

Discussion

Member takes

Implication

Key Points

Cite This Study

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