Atrial fibrillation predicts appropriate shocks in primary prevention implantable cardioverter-defibrillator patients
Key result
Prior AF predicts a ~590% higher risk of appropriate shocks in primary prevention ICD patients.
- HR 6.9
- 95% CI 1.7-27.5
- P=0.006
- n=80
Why the study?
The association of atrial fibrillation with appropriate shocks and cardiovascular mortality in primary prevention ICD patients with left ventricular dysfunction was unclear.
Does a history of atrial fibrillation predict appropriate shocks in primary prevention ICD patients with left ventricular dysfunction?
Population
80 primary prevention ICD patients with left ventricular dysfunction
Comparison
History of atrial fibrillation vs no history of atrial fibrillation
Design
Cohort study
Follow-up
Median 8 months (range 1-60)
Authors
Discussion
Loading...
Member takes
Implication
May support closer monitoring in primary prevention ICD patients with AF history; hypothesis-generating for prospective risk-stratification studies.
Study Design
Type
Cohort (n=80)
Structured PICO
Does a history of atrial fibrillation predict appropriate shocks in primary prevention ICD patients with left ventricular dysfunction?
P
Population
80 primary prevention ICD patients with left ventricular dysfunction, followed for a median of 8 months.
E
Exposure
History of atrial fibrillation (n=29)
C
Comparator
No history of atrial fibrillation (n=51)
O
Outcome
Occurrence of appropriate shockshard clinical
Main Result
Hazard Ratio: 6.9 (95% CI 1.7–27.5)
Absolute Event Rate: 24% vs 6%
p-value: p=0.006
A history of atrial fibrillation is a strong predictor of appropriate ICD shocks and cardiovascular mortality in primary prevention ICD patients with left ventricular dysfunction.
Cite This Study
Smit et al. (2006) conducted a cohort in Primary prevention ICD patients with left ventricular dysfunction (n=80). History of atrial fibrillation vs. No history of atrial fibrillation was evaluated on Occurrence of appropriate shocks (HR 6.9, 95% CI 1.7-27.5, p=0.006). A history of atrial fibrillation in primary prevention ICD patients with left ventricular dysfunction predicted appropriate shocks (24% vs 6%; HR 6.9, 95% CI 1.7-27.5, P=0.006).