Key result
Coenzyme Q10 and Cynara scolymus L improve hepatic and renal function in doxorubicin-treated rats.
Why the study?
The protective effects of coenzyme Q10 and Cynara scolymus L on doxorubicin-induced toxicity were evaluated to address doxorubicin's adverse hepatic and renal effects.
Does coenzyme Q10 or Cynara scolymus L prevent doxorubicin-induced hepatic and renal toxicity in rats?
Does coenzyme Q10 or Cynara scolymus L prevent doxorubicin-induced hepatic and renal toxicity in rats?
Pretreatment with CoQ10 and Cynara scolymus L mitigates doxorubicin-induced hepatic and renal toxicity in a rat model by reducing oxidative stress.
Offers no immediate clinical guidance; leaves open translation of CoQ10 and Cynara scolymus L benefits from rat models to humans.
OBJECTIVE: The study aims to evaluate the protective effects of coenzyme Q10 (CoQ10) and Cynara scolymus L (CS) on doxorubicin (dox)-induced toxicity. MATERIALS AND METHODS: Sixty male rats were divided into six groups. Group 1 as a control. Group 2 received dox (10 mg/kg) intraperitoneally. Group 3 received CoQ10 (200 mg/kg). Group 4 received CS (500 mg/kg). Group 5 received CoQ10 (200 mg/kg) and dox (10 mg/kg). Group 6 received CS (500 mg/kg) and dox (10 mg/kg). The rats were then evaluated biochemically and immunohistochemically. RESULTS: Dox produced a significant deterioration of hepatic and renal functional parameters. Moreover, an upsurge of oxidative stress and nitrosative stress markers. The expression of alpha-smooth muscle actin (α-SMA) was increased and proliferating cell nuclear antigen (PCNA) expression was decreased. Administration of CoQ10 and CS resulted in a significant improvement of hepatic and renal functional parameters, and an improvement of both α-SMA and PCNA. CONCLUSION: It is concluded that pretreatment with CoQ10 and CS is associated with up-regulation of favorable protective enzymes and down-regulation of oxidative stress. That can be advised as a supplement to dox-treated patients.
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Mustafa et al. (2015) studied Doxorubicin-induced toxicity (n=60). Coenzyme Q10 and Cynara scolymus L vs. Doxorubicin alone and control was evaluated on Hepatic and renal functional parameters, oxidative stress markers, α-SMA, and PCNA expression. Pretreatment with coenzyme Q10 and Cynara scolymus L significantly improved hepatic and renal functional parameters and reduced oxidative stress in doxorubicin-treated rats.
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