Key result
Coenzyme Q10 protects against doxorubicin-induced cardiotoxicity in most reviewed animal studies.
Why the study?
Doxorubicin causes acute cardiotoxicity through free radical release and lipid peroxidation, and the cardioprotective effect of coenzyme Q10 in this context needed evaluation.
Does coenzyme Q10 prevent doxorubicin-induced cardiotoxicity in animal models?
Does coenzyme Q10 prevent doxorubicin-induced cardiotoxicity in animal models?
Coenzyme Q10 shows promise as a cardioprotective supplement against doxorubicin-induced cardiotoxicity based on animal studies.
Hypothesis-generating for CoQ10 cardioprotection; leaves open translation to human doxorubicin trials.
Introduction: Doxorubicin (dox) is classified as an antineoplastic antibiotic which is known as adriamycin from the anthracycline group. Due to the release of free radicals and lipid peroxidation which can cause acute cardiotoxicity. Coenzyme Q10 is found in many cells of the body, it is an antioxidant that reduces oxidative stress and lipid peroxidation. Aim: This scoping review aims to evaluate the cardioprotective effect of coenzyme Q10 in doxorubicin-induced cardiotoxicity in animals. Methods: This review was done based on Arksey and O'Malley's methodology, reviewing published articles from October 1978 and September 2023. Results: 14 out of 11,303 articles were included from the initial search, (10 out of 14 articles found that coenzyme Q10 protect has a protection effect against doxorubicin-induced cardiotoxicity). Conclusion: The results of this review found coenzyme Q10 protects against doxorubicin cardiotoxicity. It is a promising supplement that could be used to prevent cardiotoxicity induced by doxorubicin in cancer patients.
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Abdullah et al. (2023) conducted a review in Doxorubicin-induced cardiotoxicity (n=14). Coenzyme Q10 was evaluated on Protection against doxorubicin-induced cardiotoxicity. Coenzyme Q10 demonstrated a protective effect against doxorubicin-induced cardiotoxicity in 10 out of 14 included animal studies.
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