Key result
Puerarin attenuates Ang II-induced cardiac hypertrophy by increasing miR-15b/195 and suppressing non-canonical TGFβ signaling.
Why the study?
Previous studies demonstrated puerarin has therapeutic effects on cardiac hypertrophy, but its relationship with miRNAs and TGFβ signaling was unclear.
Population
Angiotensin II-induced cardiac hypertrophy mouse model and primary cardiomyocytes
Comparison
Puerarin treatment vs no treatment
Design
Experimental study using in vivo and in vitro models
Authors
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Hypothesis-generating for puerarin in hypertrophy models; prospective trials required before any clinical consideration.
Zhang et al. (2016) studied Cardiac hypertrophy. Puerarin was evaluated on Cardiac hypertrophy features (gene expression, cell surface area, protein synthesis). Puerarin attenuated Ang II-induced cardiac hypertrophy by increasing miR-15b and miR-195 expression and suppressing the non-canonical TGFβ signaling pathway.
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