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June 6, 2018Frontiers in PharmacologyOpen Access

Nrf2 Is a Key Regulator on Puerarin Preventing Cardiac Fibrosis and Upregulating Metabolic Enzymes UGT1A1 in Rats

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Why the study?

Does puerarin prevent cardiac fibrosis in rat models of abdominal aortic banding and AngII-induced oxidative stress?

Population

Specific pathogen-free Sprague-Dawley rats weighting 150–180 g and primary cultured neonatal rat cardiac…

Comparison

Puerarin vs Sham-operated rats receiving equal volume of…

Design

Preclinical, Rats were randomly divided into three groups, Echocardiography…

Follow-up

6 weeks

Authors

SCShao-Ai CaiNHNing HouGZGan-Jian Zhao

Discussion

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Overview

Puerarin attenuates fibrosis in rat models; leaves open translation to human cardiac disease.

Structured PICO

Does puerarin prevent cardiac fibrosis in rat models of abdominal aortic banding and AngII-induced oxidative stress?

P
Population
Specific pathogen-free Sprague-Dawley rats weighting 150–180 g (n=18) and primary cultured neonatal rat cardiac fibroblasts (NRCFs).
I
Intervention
Puerarin (50 mg/kg/day intraperitoneal injection for 6 weeks in vivo; 10-1000 µM in vitro)
C
Comparator
Sham-operated rats receiving equal volume of normal saline; untreated or AngII-treated cells
O
Outcome
Cardiac fibrosis (collagen volume fraction, collagen I and III expression) and oxidative stress (ROS levels)surrogate

Puerarin prevents cardiac fibrosis via activation of Nrf2 and inactivation of p38-MAPK in preclinical models.

Cite This Study

Cai et al. (2018) studied this question.

synapsesocial.com/papers/6a886a5fceefe68dba4fce94https://doi.org/10.3389/fphar.2018.00540
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