Key result
Noncrimped Dacron grafts show the lowest thrombogenicity among 4-mm arterial prostheses in dogs.
Why the study?
The thrombogenicity of different 4-mm diameter arterial prostheses and their predictive value for long-term implantation success were not well established.
Does the type of 4-mm arterial prosthesis affect graft thrombogenicity and implantation success in a dog model?
Population
Dogs with 19 experimental left coronary artery implantations
Comparison
Three Dacron, one expanded Teflon, and one preserved umbilical vein prostheses
Design
Preclinical experimental study
Follow-up
Six hours, one week, and long-term implantation
Authors
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Hypothesis-generating for noncrimped Dacron in small-vessel bypass; should not change human practice without further study.
Does the type of 4-mm arterial prosthesis affect graft thrombogenicity and implantation success in a dog model?
Noncrimped Dacron grafts showed the lowest thrombogenicity in a dog model, suggesting potential utility for coronary and below-the-knee bypass when autogenous vessels are unavailable.
Lester R. Sauvage (1979) studied Graft thrombogenicity. 4-mm diameter arterial prostheses vs. Different types of prostheses was evaluated on Graft thrombogenicity. Noncrimped Dacron grafts demonstrated the lowest thrombogenicity among tested 4-mm arterial prostheses in dogs, indicating potential for left coronary artery and below-knee use.
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