Key result
Septal myectomy linked to a ~60 mmHg reduction in LVOT gradient in HOCM patients.
Why the study?
Management of hypertrophic obstructive cardiomyopathy has evolved over fifty years, but detailed surgical outcome data from large centers are needed.
Does septal myectomy improve symptoms and echocardiographic parameters in patients with hypertrophic obstructive cardiomyopathy?
Population
115 patients with HOCM undergoing surgical myectomy for LVOTO between 1997 and 2016
Comparison
Preoperative versus postoperative status after septal myectomy
Design
Retrospective analysis of surgical database
Follow-up
Up to 11.3 years
Authors
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Supports septal myectomy for symptom relief in obstructive HCM; leaves open need for randomized confirmation.
Observational (n=115)
No
Does septal myectomy improve symptoms and echocardiographic parameters in patients with hypertrophic obstructive cardiomyopathy?
Absolute Event Rate: 9.7% vs 70.1%
Surgical septal myectomy for hypertrophic obstructive cardiomyopathy is an effective intervention that significantly reduces LVOT gradient and improves NYHA functional class with low operative risk.
Kuehl et al. (2017) conducted an observational in Hypertrophic obstructive cardiomyopathy (n=115). Surgical septal myectomy vs. Preoperative baseline was evaluated on Left ventricular outflow tract gradient. Surgical septal myectomy in patients with hypertrophic obstructive cardiomyopathy effectively reduced the mean left ventricular outflow tract gradient from 70.1 mmHg to 9.7 mmHg.
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