Sodium hydrogen sulfate as effective and reusable heterogeneous catalyst for the one-pot preparation of amidoalkyl naphthols

An efficient synthesis of amidoalkyl naphthols using sodium hydrogen sulfate as heterogeneous catalyst is described.The thermal solvent-free and microwave green procedures offer advantages such as shorter reaction times, simple work-up, excellent yield, recovery and reusability of catalyst.It is noteworthy that 1-amidomethyl-2-naphthols can be converted in to important 'drug like' 1-aminomethyl-2-naphthols derivatives by amide hydrolysis reaction.