The antifungal metabolite ratjadone (1) was isolated from the myxobacterium Sorangium cellulosum, strain So ce360. Production was achieved by fermentation in the presence of the adsorber resin XAD‐16, extraction and separation by RP chromatography. The structure of 1 was determined by spectroscopic methods. It is characterized by a 4‐hydroxytetrahydropyran and a 5,6‐dihydropyran‐2‐one ring which are connected by an unsaturated C11 carbon chain. The polyketide origin of 1 was proven by feeding experiments with 13C‐labeled precursors and NMR spectroscopic examinations.
No takes yet. Share an insight, caveat, or question.
Schummer et al. (1995) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: