Key result
Combined pleural fluid IL-1beta and neutrophil count show moderate diagnostic accuracy for parapneumonic effusion.
Why the study?
Diagnosis of parapneumonic effusions is often based on clinical criteria due to frequently negative microbiology results, necessitating evaluation of proinflammatory interleukins as diagnostic markers.
What is the diagnostic value of proinflammatory interleukins (IL-6, IL-8, IL-1beta) in pleural fluid for identifying parapneumonic effusions?
Observational (n=266)
What is the diagnostic value of proinflammatory interleukins (IL-6, IL-8, IL-1beta) in pleural fluid for identifying parapneumonic effusions?
The combination of pleural fluid IL-1beta and total neutrophil count provides moderate diagnostic accuracy for identifying parapneumonic effusions.
May aid pleural fluid analysis in suspected parapneumonic effusion; leaves open prospective validation before clinical adoption.
Pleural effusion appears in approximately 40% of patients with pneumonia. Given that microbiology results are often negative, its diagnosis is frequently based on clinical criteria. Our study consisted of 266 patients, divided into infectious (n = 34), tuberculous (n = 54), paraneoplastic (n = 63), miscellaneous exudates (n = 53), and transudates (n = 62). Interleukin (IL)-6, IL-8, and IL-1beta were measured in the pleural fluid and serum of all patients, as well as the different cell populations in the pleural fluid. Analysis of the receiver operating characteristic curves of the different ILs in pleural fluid for the diagnosis of parapneumonic/empyematous effusion showed IL-6 with a sensitivity of 38.2% and specificity of 97.4%, IL-8 with a sensitivity of 73.5% and specificity of 65.1%, IL-1beta with a sensitivity of 55.6% and specificity of 91.3%, and total neutrophil count in pleural fluid (PNEU) with a sensitivity of 62.9% and specificity of 91.1%. The combination of IL-1beta and PNEU improved the yield, with a sensitivity of 75.7% and a specificity of 83.1%.
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José et al. (2010) conducted an observational in Pleural effusion (n=266). Pleural fluid IL-6, IL-8, IL-1beta, and neutrophil count was evaluated on Diagnosis of parapneumonic/empyematous effusion. The combination of pleural fluid IL-1beta and total neutrophil count diagnosed parapneumonic/empyematous effusion with a sensitivity of 75.7% and a specificity of 83.1%.
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