Key result
Oral Cochinchina momordica seed or Quillaja saponaria-A extracts enhance FMDV-specific IgG responses in mice.
Why the study?
The effects of oral administration of Quillaja saponaria-A and Cochinchina momordica seed extracts on immune responses to foot-and-mouth disease vaccination in mice were evaluated.
Does oral administration of ECMS or Quil-A improve immune responses to FMD vaccine in mice?
RCT (n=42)
randomly divided
Does oral administration of ECMS or Quil-A improve immune responses to FMD vaccine in mice?
p-value: p=<0.05
Oral administration of ECMS or Quil-A enhances the immune response to FMDV vaccination in mice, with ECMS showing better immunomodulatory effects.
Oral ECMS or Quil-A boosted FMDV IgG responses in mice; hypothesis-generating for veterinary adjuvants, needs livestock trials.
This study was designed to evaluate the effects of oral administration of extracts from Cochinchina momordica seed (ECMS) or Quillaja saponaria-A (Quil-A) on the immune responses in mice immunized with foot and mouth disease virus (FMDV)-serotype O vaccine. Forty-two imprinting control region (ICR) mice were randomly divided into seven groups of 6 animals in each group, and a dose of 400 μg of Quil-A or ECMS was orally administered for 1,, 2 or 3 days. After that, the animals were subcutaneously immunized twice with FMD vaccine at 3-week intervals and blood samples were collected 2-weeks after boosting for measurement of FMDV-specific IgG and its subclasses. Spleens were collected for lymphocytes proliferation assay. Results indicated that serum FMDV-specific IgG and the IgG subclass responses were significantly enhanced in mice orally administered ECMS or Quil-A when compared with the control group (p<0.05). Lymphocytes proliferation response to FMD vaccine was significantly enhanced by ECMS compared with the control (p<0.05). This study illustrates that ECMS induced immunomodulatory effects and performed better than Quil-A.
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Xiao et al. (2013) conducted an RCT in foot and mouth disease virus (FMDV)-serotype O vaccination (n=42). extracts from Cochinchina momordica seed (ECMS) or Quillaja saponaria-A (Quil-A) vs. control group was evaluated on serum FMDV-specific IgG and the IgG subclass responses (p=<0.05). Oral administration of extracts from Cochinchina momordica seed or Quillaja saponaria-A significantly enhanced serum FMDV-specific IgG and IgG subclass responses in mice (p<0.05).
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