Key result
Mild hyperbaric oxygen therapy increases P300 voltage ~119% in a single post-concussive patient.
Why the study?
The effects of mild hyperbaric oxygen therapy on cognitive function and symptom relief in post-concussive symptoms following motor vehicle accidents are not well established.
Does mild hyperbaric oxygen therapy improve cognitive function and symptom relief in a patient with post-concussive symptoms?
Case Report (n=1)
No
Does mild hyperbaric oxygen therapy improve cognitive function and symptom relief in a patient with post-concussive symptoms?
Absolute Event Rate: 9.2% vs 4.2%
Mild hyperbaric oxygen therapy may improve cognitive function and alleviate symptoms in patients with post-concussive syndrome, warranting further investigation in RCTs.
Does not support practice change after one case; hypothesis-generating for mild hyperbaric oxygen in post-concussion, needs RCTs.
This case report examines the impact of mild hyperbaric oxygen therapy (mHBOT) on cognitive function and symptom relief in a 35-year-old male presenting with concussive symptoms (CS) following a motor vehicle accident (MVA). The patient underwent 10 mHBOT sessions over five weeks (40 minutes per session at 1.5 ATA with 32% oxygen). Post-treatment assessments revealed significant improvements, including an increase in P300 voltage from 4.2 µV to 9.2 µV, aligning with the normative range of 8 - 21 µV. Electroencephalogram (EEG) analysis demonstrated enhanced alpha and theta band activity, reflecting improved cognitive processing and attentional regulation. Clinically, the patient reported reduced headache severity, improved sleep quality, and decreased pain intensity. These findings suggest that mHBOT may support neuroplasticity, mitigate inflammation, and restore cognitive function in patients with CS. Further research, including randomized controlled trials (RCTs), is warranted to validate mHBOT’s efficacy and explore its long-term benefits in traumatic brain injury (TBI) rehabilitation.
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Hambright et al. (2025) conducted a case report in Post-Concussive Symptoms (n=1). Mild-Hyperbaric Oxygen Therapy (mHBOT) vs. Baseline was evaluated on P300 voltage. Mild hyperbaric oxygen therapy increased P300 voltage from 4.2 µV to 9.2 µV and reduced headache severity from 9/10 to 3/10 in a 35-year-old male with post-concussive symptoms.
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