Key result
Higher BMI predicts worse functional class and shorter 6MWD in idiopathic and heritable PAH.
Why the study?
The relationship between BMI, functional class, and 6 min walk distance in Group 1 pulmonary arterial hypertension was unclear.
Is increased body mass index (BMI) associated with worse functional class and shorter 6-minute walk distance in patients with idiopathic and heritable PAH?
Cohort
Yes
Is increased body mass index (BMI) associated with worse functional class and shorter 6-minute walk distance in patients with idiopathic and heritable PAH?
Increased BMI is associated with worse functional class and shorter 6-minute walk distance in patients with idiopathic and heritable PAH, potentially linked to altered estrogen metabolism.
Higher BMI was associated with worse PAH functional status; hypothesis-generating for weight management trials.
The hypothesis that a relationship exists between body mass index (BMI), functional class, and 6 min walk distance (6MWD) in Group 1-pulmonary arterial hypertension (PAH) was examined. Analysis of data from the UK National Cohort Study for heritable pulmonary arterial/idiopathic PAH suggests increased BMI is a predictor of worse functional class and shorter 6MWD; increased body-weight in mice and man may be associated with increased estrogen metabolism.
No takes yet. Share an insight, caveat, or question.
MacLean et al. (2022) conducted a cohort in Idiopathic and heritable pulmonary arterial hypertension (PAH). Body mass index (BMI) was evaluated on Functional class and 6 minute walk distance (6MWD). Increased body mass index was a predictor of worse functional class and shorter 6-minute walk distance in patients with idiopathic and heritable pulmonary arterial hypertension.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: