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Corona Virus Disease 2019 (COVID-19) has caused a global pandemic in over 100 countries. Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) was identified as the pathogen of COVID-19. Both SARS-CoV-2 and SARS-CoV belong to the subgenus sarbecvirus of Coronaviridae. One major structural protein Spike (S) has attracted great attention because of its function in recognizing receptor, angiotensin-converting enzyme 2 (ACE2). ACE2 binds to the receptor-binding motif (RBM) in the receptor-binding domain (RBD) of SARS-CoV-2 and SARS-CoV.
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Luan et al. (2020) studied this question.
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