Why the study?
Elevated blood pressure is a key modifiable risk factor for cardiovascular disease and progression to end-stage kidney disease in CKD, but evidence for optimal blood pressure targets is limited and inconsistent across guidelines.
Does a lower target blood pressure improve renal and cardiovascular outcomes in patients with chronic kidney disease?
Population
Patients with chronic kidney disease including those with and without proteinuria, children, and kidney transplant recipients
Comparison
Lower target blood pressure (e.g. ≤130/80 mmHg) versus standard target blood pressure (e.g. ≤140/90 mmHg)
Design
Commentary on KDIGO Clinical Practice Guideline with systematic review evidence
Authors
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KDIGO BP targets in CKD require cautious use given low-quality evidence; leaves open urgent need for new RCTs to guide practice.
Does a lower target blood pressure improve renal and cardiovascular outcomes in patients with chronic kidney disease?
The KDIGO guidelines for blood pressure management in CKD reveal a significant lack of high-quality RCT evidence, relying heavily on low-grade recommendations.
Matthew A. Roberts (2013) conducted a review in Chronic kidney disease. Blood pressure targets was evaluated. The KDIGO guideline on blood pressure management in chronic kidney disease reveals a lack of high-quality RCT evidence, with most recommendations graded as low quality.
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