Key result
Metabolomics profiling identifies altered amino acids and lipids as potential biomarkers for early hypertension detection.
Why the study?
Hypertension is a multifactorial disorder with increasing incidence worldwide, and metabolomics profiling may help understand its underlying causes and control blood pressure.
Metabolomics profiling represents a valuable tool for discovering novel biomarkers and elucidating the pathophysiological pathways involved in hypertension and blood pressure regulation.
Metabolomics findings remain exploratory in hypertension; leaves open clinical utility pending prospective validation.
Hypertension is a chronic health condition in which blood pressure is usually elevated beyond normal levels. It can progress with serious complications if left undetected and untreated. Incidence of hypertension is on the increase worldwide with debilitating consequences on the health systems of many countries. It is a multifactorial disorder that requires a multi-pronged approach to address it. One such approach is the use of metabolomics or metabolite profiling to understand its underlying cause and possibly control it. Changes in metabolites profiles have been used to accurately predict so many disease conditions in addition to identifying possible biomarkers and pathways associated in their pathogenicity. This will enable their early detection, diagnosis and treatment as well as likely complications that may arise and also assist in development of biomarkers for clinical uses. The objective of this review therefore is to present some of the current knowledge on the application of metabolomics profiling in hypertension and blood pressure control.
No takes yet. Share an insight, caveat, or question.
Onuh et al. (2020) conducted a review in Hypertension. Metabolomics profiling was evaluated. Metabolomics profiling identifies changes in metabolites such as amino acids, lipids, and Krebs cycle intermediates, offering potential biomarkers for the early detection and understanding of hypertension.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: