Key result
Angiotensin II triggers neutrophil chemoattractant release from cultured endothelial cells within 1 minute.
Why the study?
It was unclear whether angiotensin II affects neutrophil-mediated inflammatory responses via endothelial cell release of neutrophil chemoattractants.
Does angiotensin II cause the release of neutrophil chemoattractant from cultured endothelial cells?
Population
Cultured bovine and human endothelial cells including pulmonary arterial, aortic, and umbilical vein cells
Comparison
Exposure to angiotensin II, angiotensin I, bradykinin, and various inhibitors versus unexposed cells
Design
Preclinical experimental study
Authors
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May link Ang II to rapid neutrophil recruitment in vitro; hypothesis-generating for vascular inflammation, should not change practice.
Does angiotensin II cause the release of neutrophil chemoattractant from cultured endothelial cells?
Angiotensin II stimulates vascular endothelial cells to release a neutrophil chemoattractant, suggesting a mechanism for neutrophil accumulation in vascular inflammation.
Farber et al. (1990) studied this question. Angiotensin II was evaluated on Release of neutrophil chemoattractant activity. Angiotensin II stimulated the release of a neutrophil chemoattractant from cultured bovine and human endothelial cells within 1 minute of exposure.
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