Why the study?
The association between positive fluid balance and clinical outcomes in pediatric patients with acute lung injury was unclear.
Population
320 pediatric patients with acute lung injury
Comparison
Positive fluid balance vs lower or negative fluid balance
Design
Post-hoc analysis of previously collected data
Follow-up
First 72 hours after ALI in the PICU
Key result
Positive fluid balance during the first 72 hours was associated with a significant increase in mortality and prolonged mechanical ventilation in pediatric patients with acute lung injury.
Authors
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May support fluid-restrictive approaches in pediatric ALI; extends adult data but remains hypothesis-generating.
Cohort (n=320)
Flori et al. (2011) conducted a cohort in Acute lung injury (ALI) (n=320). Positive fluid balance was evaluated on Mortality. Positive fluid balance during the first 72 hours was associated with a significant increase in mortality and prolonged mechanical ventilation in pediatric patients with acute lung injury.
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